Receptacle for pharmaceutical packaging with a thickness profile for a lubricant layer

A kit, comprising:

• a receptacle, the receptacle comprising:
• an elongate barrel section having a direction of elongate extension and an axis in the direction of elongate extension, an axial position p being determined along the axis, the elongate barrel section extending from an axial position pA to an axial position pB, an elongate barrel section length LB being a distance between pA and pB;
• a side wall extending over the elongate barrel section, the side wall having an inner surface bordering an interior, the interior having a diameter;
• and
• a layer of a lubricant located on at least a part of the inner surface, at a given axial position p on the axis between pA and pB, a thickness of the side wall, a thickness of the layer, and the diameter of the interior are each determined as an angular mean in a cross-sectional plane perpendicular to the axis at the axial position p, a portion X of the axis extends from a first axial position p1 to a second axial position p2 such that the following criteria are satisfied:
• both the first axial position p1 and the second axial position p2 lie between pA and pB;
• a portion length LX is a distance between the first axial position p1 and the second axial position p2;
• the portion length LX is at least a half of the elongate barrel section length LB;
• and
• the layer extends over the entire portion X;
• a mean thickness Tmean of the layer is determined in the portion X;
• a position pm is the midpoint between p1 and p2;
• TA is a mean thickness of the layer for a section from p1 to pm;
• TB is a mean thickness of the layer for a section from pm to p2;
• a ratio TA:TB is in a range from 5:1 to 1:5;
• wherein the layer has a maximum layer thickness Tmax determined between p1 and p2, a minimum layer thickness Tmin determined between p1 and p2 and a value of Tmin/Tmax is at least 0.7, and one or more criteria are satisfied, the criteria being selected from the group consisting of:
• the elongate barrel section length LB is in a range from 3 cm to 20 cm;
• a mean value of the diameter of the interior determined over the range pA to pB is in a range from 0.4 cm to 4 cm;
• a mean thickness of the sidewall determined over the range pA to pB is in a range from 0.3 mm to 4 mm;
• and
• a volume of the interior is in a range from 0.1 mL to 150 mL;
• and a charge adapted and arranged to be positioned in the interior such that:
• the charge seals a cross section of the interior between inner surfaces of the side walls;
• the charge has a front end at the axial position closest to pB at which the charge contacts the layer or the inner surface;
• the charge has a back end at the axial position closest to pA at which the charge contacts the layer or the inner surface;
• a length of the charge LC is a distance between the front end and the back end;
• the charge has a charge axial position that is an axial position of the front end;
• and
• the charge is movable in a direction parallel to the axis with a dynamic friction g that is a function of the charge axial position.

An assembly, comprising:

• a receptacle, the receptacle comprising:
• an elongate barrel section having a direction of elongate extension and an axis in the direction of elongate extension, an axial position p being determined along the axis, the elongate barrel section extending from an axial position pA to an axial position pB, an elongate barrel section length LB being a distance between pA and pB;
• a side wall extending over the elongate barrel section, the side wall having an inner surface bordering an interior, the interior having a diameter;
• an aperture;
• and
• a layer of a lubricant located on at least a part of the inner surface, at a given axial position p on the axis between pA and pB, a thickness of the side wall, a thickness of the layer, and the diameter of the interior are each determined as an angular mean in a cross-sectional plane perpendicular to the axis at the axial position p, a portion X of the axis extends from a first axial position p1 to a second axial position p2 such that the following criteria are satisfied:
• both the first axial position p1 and the second axial position p2 lie between pA and pB;
• a portion length LX is a distance between the first axial position p1 and the second axial position p2;
• the portion length LX is at least a half of the elongate barrel section length LB;
• and
• the layer extends over the entire portion X;
• a mean thickness Tmean of the layer is determined in the portion X;
• a position pm is the midpoint between p1 and p2;
• TA is a mean thickness of the layer for a section from p1 to pm;
• TB is a mean thickness of the layer for a section from pm to p2;
• a ratio TA:TB is in a range from 5:1 to 1:5;
• wherein the layer has a maximum layer thickness Tmax determined between p1 and p2, a minimum layer thickness Tmin determined between p1 and p2 and a value of Tmin/Tmax is at least 0.7, and one or more criteria are satisfied, the criteria being selected from the group consisting of:
• the elongate barrel section length LB is in a range from 3 cm to 20 cm;
• a mean value of the diameter of the interior determined over the range pA to pB is in a range from 0.4 cm to 4 cm;
• a mean thickness of the sidewall determined over the range pA to pB is in a range from 0.3 mm to 4 mm;
• and
• a volume of the interior is in a range from 0.1 mL to 150 mL;
• a charge positioned in the interior sealing a cross section of the interior;
• and
• a liquid pharmaceutical composition contained in the interior and located between the sealed cross section and the aperture, the assembly being adapted and arranged for the liquid pharmaceutical composition to be ejected through the aperture by movement of the charge in a direction parallel to the axis.