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US 11,896,800 B2Granted
Enhanced cancer immunotherapy by microneedle patch-assisted delivery
AssigneeNorth Carolina State University
InventorsZhen Gu, Chao Wang, Yanqi Ye
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Abstract
Disclosed herein are self-degradable microneedle devices for the controlled-release of an immunotherapeutic agent. Also disclosed are methods for treating a disease (for example, cancer) using a self-degradable microneedle patch for the sustained delivery of an immunotherapeutic agent (for example, a PD1 antibody).
Claims10
A method for treating a skin cancer in a subject in need thereof, comprising:
- providing a microneedle patch to a subject, wherein the microneedle patch comprises:
- a plurality of microneedles each having a base end and a tip;
- a substrate to which the base ends of the microneedles are attached or integrated;
- acid-degradable nanoparticles, wherein the nanoparticles encapsulate an immunotherapeutic agent and a pH altering agent;
- inserting the microneedles into a biological barrier, wherein the pH altering agent decreases the pH within the acid-degradable nanoparticles, and wherein the decrease in the pH degrades the nanoparticle and releases the immunotherapeutic agent into the subject in a controlled-release manner;
- wherein the immunotherapeutic agent comprises an anti-PD1 antibody and an anti-CTLA4 antibody.
3 more elements
Dependencies are inferred from the claim text.