Biomaterial implants and methods of making the same
AssigneeGlobus Medical, Inc.
InventorsJoshua Cige, Archana Bhat, Joanna Marquez
Life of this patent
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Abstract
Biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. The biomaterials may include demineralized cortical fibers, which help to promote bone repair.
Claims20
A method of making an implantable biomaterial for aiding bone regeneration, the method comprising:
- obtaining whole bone;
- sectioning and debriding the whole bone into cortical rings;
- machining the cortical rings into cortical fibers having lengths of 10-50 mm, widths of 0.5-2 mm, and thicknesses of 0.1-1 mm;
- demineralizing the cortical fibers to form demineralized cortical fibers;
- suspending and entangling the demineralized cortical fibers in an aqueous solution;
- compressing the demineralized cortical fibers in solution in a mold to form a molded biomaterial composition of a given shape;
- freezing the molded biomaterial composition;
- and
- freeze-drying the molded biomaterial composition to form the implantable biomaterial;
- wherein the cortical rings are cleaned with a 0.05-0.15% v/v sodium deoxycholate solution, a 2-6% hydrogen peroxide solution, and an isopropyl alcohol solution.
A method of promoting bone or wound healing in a mammal, the method comprising:
- cleaning cortical fibers with a 0.05-0.15% v/v sodium deoxycholate solution, a 2-6% hydrogen peroxide solution, and an isopropyl alcohol solution;
- demineralizing the cleaned cortical fibers to form demineralized cortical fibers;
- entangling and compressing the demineralized cortical fibers having lengths of 10-50 mm, widths of 0.5-2 mm, and thicknesses of 0.1-1 mm into a bone graft, wherein any excess water is drained from the bone graft during compressing;
- administering the bone graft into a target repair site to facilitate repair or regeneration of bone at the target repair site.
A method of making an implantable biomaterial for aiding bone regeneration, the method comprising:
- obtaining whole bone;
- separating the whole bone into condyles and cortical shafts;
- grinding the condyles into cortico-cancellous chips having a size less than 1.5 mm;
- machining the cortical shafts into cortical fibers having a size of 15-30 mm;
- demineralizing the cortical fibers;
- combining the cortico-cancellous chips and demineralized cortical fibers with a carrier, wherein the carrier is a reverse phase hydrogel;
- wherein prior to demineralizing, the cortical shafts are cleaned with a 0.05-0.15% v/v sodium deoxycholate solution, a 2-6% hydrogen peroxide solution, and an isopropyl alcohol solution.
Dependencies are inferred from the claim text.