Multiparticulate L-carnitine compositions and related methods

An oral controlled-release multiparticulate dosage form comprising an L-carnitine carried on a plurality of individually enteric coated particulates that independently disperse in a person's stomach after oral ingestion and travel through the stomach and past a pyloric sphincter, the individually enteric coated particulates comprising (a) a spheronized extrudate solid core including the L-carnitine intermixed with a pharmaceutically acceptable binder and a pharmaceutically acceptable filler and (b) an enteric coating over the solid core, a predominant component of the enteric coating being an enteric polymer, wherein the solid core is spheroidal and comprises 30%-90% w/w of the L-carnitine, 15%-70% w/w microcrystalline cellulose filler, and 0.5%-1.5% w/w hydroxypropyl methylcellulose binder.