Core tablet composite preparation comprising mosapride and rabeprazole

A method of preparing a mosapride- and rabeprazole-containing tablet-in-tablet combined preparation for oral administration, the method comprising:

• preparing an inner core containing rabeprazole or a pharmaceutically acceptable salt thereof as an active ingredient;
• preparing immediate-release layer granules containing mosapride or a pharmaceutically acceptable salt thereof as an active ingredient, a filler, a disintegrant, and an additive and sustained-release layer granules containing mosapride or a pharmaceutically acceptable salt thereof as an active ingredient, a filler, a disintegrant, a release-modifying agent, and an additive;
• feeding the immediate-release layer granules into a punch die of a tablet press machine;
• adding the inner core to the punch die into which the immediate-release layer granules have been fed;
• applying pre-pressure to the punch die to which the inner core has been added;
• feeding the sustained-release layer granules into the punch die to which pre-pressure has been applied;
• and
• performing tableting while applying main pressure to the punch die into which the sustained-release layer granules have been fed such that a surface area of the inner core surrounded by the immediate-release layer granules is larger than a surface area of the inner core surrounded by the sustained-release layer granules,
• wherein the inner core is positioned more toward the immediate-release layer granules of an outer layer part.