Method for the formulation of oil-soluble substances, and powders obtainable thereof
AssigneeRoquette America, Inc.
InventorCarmen Popescu
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Abstract
The invention relates to a new method for the formulation of oily substances, and to powders and solid dosage forms obtainable thereof. The process comprises a step of spray-drying of an oil-in-water emulsion comprising an octenyl succinate starch and a maltodextrin.
Claims45
A process for preparation of a powder by electrostatic spray-drying of an oil-in-water emulsion, wherein said oil-in-water emulsion has an oily phase comprising one or more oils selected from the group consisting of corn oil, castor oil, soybean oil, palm oil, coconut oil, cottonseed oil, olive oil, canola oil, safflower oil, sesame oil, palm kernel oil, sunflower oil, peanut oil, and combinations thereof, and wherein said oil-in-water emulsion comprises an octenyl succinate starch and a maltodextrin in a weight ratio of octenyl succinate starch to maltodextrin selected within a range of from 1:10 to 1:40,
- and wherein the powder has:
- a bulk density of at least 0.30 g/ml,
- a tapped density of at least 0.30 g/ml, and
- a Carr's index lower than 15%, wherein the Carr's index (C) is calculated as follows:
- C
- =
- 1
-
- 0
-
- 0
- ×
- (
- 1
- -
- ρ
- B
- ρ
- T
- )
- wherein
- ρB is the bulk density of the powder, and
- ρB is the tapped density of the powder.
Dependencies are inferred from the claim text.