US 11,896,715 B2 · In vivo bulking agent, injection comprising same, and preparation method therefor

Abstract

The present invention relates to an in-vivo bulking agent which can be used as a medicinal agent for prevention or treatment of at least one disease selected from the group consisting of urinary incontinence, fecal incontinence, and gastroesophageal reflux or as a filler for use in a plastic surgery procedure, and to a preparation method therefor. The in-vivo bulking agent can exhibit a bulking effect when injected into the body and particularly, is highly biocompatible because a first composition in which silicone particles are coated with a zwitterionic polymer having a surfactant property is introduced into a second composition, whereby the bulking agent can inhibit inflammatory reactions in vivo.

Claims14

Dependent claims

An in-vivo bulking agent formulated as an injectable composition, comprising:

a first composition including polydimethylsiloxane (PDMS) particles and a zwitterionic polymer surrounding a surface of the polydimethylsiloxane particles;
and
a second composition having a viscosity of 100 to 1500 cps at room temperature, wherein the zwitterionic polymer of the first composition has a surfactant property, and wherein the zwitterionic polymer is included in an amount of 0.1 to 5 parts by weight of based on 100 parts by weight of the polydimethylsiloxane particles and the zwitterionic polymer is a random copolymer including a first monomer having a zwitterion ion and a second monomer containing an acrylic acid ester, wherein the first monomer is one or more selected from the group consisting of methacryloyloxyethyl phosphorylcholine (MPC), carboxybetaine methacrylate (CBMA), and sulfobetaine methacrylate (SBMA).

Dependencies are inferred from the claim text.

Facts

Application

17/621,587Filed 11 Jun 2020

Priority

KR 10-2019-007389821 Jun 2019

Published

US 2022/0354790 A110 Nov 2022

Granted

13 Feb 2024

Term ends

Not estimatedThe source records don’t support an estimate.

Classification23 codes

A61K 9/1641
Organic macromolecular compounds: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene…
A61L 27/50
Materials for grafts or prostheses or for coating grafts or prostheses: materials characterised by their function or physical properties , e.g.…
A61K 8/0241
Characterised by special physical form: containing particulates characterized by their shape and/or structure
A61K 8/8158
Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon…:…

In vivo bulking agent, injection comprising same, and preparation method therefor

Life of this patent

In vivo bulking agent, injection comprising same, and preparation method therefor

Life of this patent

Abstract

Claims14