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US 11,896,713 B2Granted
Strategies to enhance lung cancer treatment
AssigneeRutgers, The State University of New Jersey
InventorsTamara Minko, Olga B. Garbuzenko
Life of this patent
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Abstract
A nanocarrier containing a combination of bioactive agents is provided. The nanocarrier allows for targeted delivery of the agents to cancer cells with minimized side effect.
Claims17
A nanocarrier system formulated for in vivo delivery of an anticancer agent by inhalation, comprising:
- (a) a lipid nanoparticle comprising a lipid matrix consisting essentially of at least one lipid that is solid at room temperature and at least one lipid that is liquid at room temperature;
- (b) an anticancer agent incorporated in imperfections in the lipid matrix;
- (c) a first group of polyethylene glycols (PEGs) extending from the surface of the nanoparticle, wherein the PEGs each have an inner terminus bonded to an anchor lipid in the nanoparticle and an outer terminus;
- (d) a ligand bonded to the outer terminus of the first group of PEGs, wherein the ligand is specific to receptors overexpressed in cancer cells;
- and
- (e) one or more siRNAs distributed on the surface of the nanoparticle;
- wherein the lipid nanoparticle is not a liposome.
4 more elements
Dependencies are inferred from the claim text.