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US 11,896,705 B2Granted
Functionalized polypeptides useful in hair treatment
AssigneesUAB Ferentis, Ranjithkumar Ravichandran
InventorsJaywant Phopase, Ranjithkumar Ravichandran
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Abstract
Disclosed is a polypeptide having a base amino acid sequence and wherein at least two amino acid residue side chains are substituted with functional Michael acceptor groups. Also disclosed are cosmetic compositions including the polypeptide, a method for repairing damaged hair using the polypeptide or composition, and to the use of the polypeptide or composition in such methods.
Claims15
A cosmetic composition comprising a polypeptide for hair repair comprising:
- a polypeptide base amino acid sequence (P), and
- at least two amino acid residue side chains from the polypeptide base amino acid sequence (P),
- wherein the at least two amino acid residue side chains are substituted with functional Michael acceptor groups,
- wherein at least one of the at least two amino acid residue side chains has the Michael acceptor group (X) conjugated to the amino base of the amino acid residue (R), conforming to the following structure:
- wherein the polypeptide base amino acid sequence (P) is from about 25 to about 1000 amino acids and is selected from the group consisting of:
- a natural protein or a fragment thereof and Gly-(Pro-Lys-Gly)4(Pro-Hyp-Gly)4(Asp-Hyp-Gly)4 or (Pro-Lys-Gly)4(Pro-Hyp-Gly)4(Asp-Hyp-Gly)4.
3 more elements
Dependencies are inferred from the claim text.