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AssigneeThe Australian National University
InventorsRoss Wentworth Stephens, Gregory David Tredwell, Karen Joanne Knox, Lee Andrew Philip, Rebecca Greenlees, Keira Beattie
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The invention relates to a radiolabelled material comprising a polymer, a radioactive isotope, and an immobilizing agent, wherein the immobilizing agent is capable of immobilizing the radioactive isotope on or in the polymer, and wherein the immobilizing agent is a macromolecule comprising a polycation with multiple pendant metal-chelating side-chains. The invention also relates to a process for making a radiolabelled material, to use of a radiolabelled material for the preparation of medicaments for treating cancer and/or for radiation imaging and to use of a radiolabelled material in the treatment of cancer. There is further described use of an immobilizing agent to immobilize a radioactive isotope on or in a polymer.
A radiolabelled material comprising:
The radiolabelled material according to any preceding claim, wherein the metal-chelating agent is selected from the group consisting of ethylene diamine tetraacetic acid (EDTA), 1,4,7,10-tetraazacyclododecane-1,4,7,10-N,N′,N″,N′″-tetraacetic acid (DOTA), diethylene triamine pentaacetic acid (DTPA), mercaptoacetyltriglycine (MAG3), 6-Hydrazinopridine-3-carboxylic acid (Hynic), dimercaptosuccinic acid (DMSA), ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid (EGTA), triethylenetetramine (TETA), 1,4,7,10-tetraazacyclotridecane-1,4,7,10-N,N′,N″,N′″-tetraacetic acid (TRITA), 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA), deferoxamine (desferral), sarcophagine (SarAr), 1,4,7,10-tetraazacyclododecane-1,4,7,10-N,N′,N″,N′″-tetra(methylene) phosphonic acid (DOTMP);
The radiolabelled material of claiml, further comprising at least one non-radioactive carrier metal.
Dependencies are inferred from the claim text.