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US 11,896,677 B2Granted
Compositions and methods for delivery of RNA
AssigneeHDT Bio Corp.
InventorsAmit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
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Abstract
The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
Claims30
A composition, wherein the composition comprises:
- nucleic acids, wherein the nucleic acids comprise a sequence encoding for a protein region;
- lipid nanoparticles, wherein the lipid nanoparticles are characterized as having a z-average diameter particle size measurement of 20 nm to about 60 nm when measured using dynamic light scattering, and wherein the lipid nanoparticles comprise:
- a surface comprising cationic lipids;
- and
- a hydrophobic core that comprises liquid oil, wherein lipids present in the hydrophobic core are in liquid phase at 25 degrees Celsius,
- wherein the nucleic acids are complexed to the cationic lipids to form nucleic acid-lipid nanoparticle complexes;
- and
- an adjuvant for innate immune stimulation.
5 more elements
Dependencies are inferred from the claim text.