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US 11,896,665 B2Granted
Human herpesvirus immunotherapy
AssigneeThe Council of the Queensland Institute of Medical Research
InventorsRajiv Khanna, Dasari Vijayendra
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AssigneeThe Council of the Queensland Institute of Medical Research
InventorsRajiv Khanna, Dasari Vijayendra
Estimating the term…
An isolated protein comprises respective amino acid sequences of each of a plurality of CTL epitopes from two or more different herpesvirus antigens and further comprises an intervening amino acid or amino acid sequence between at least two of said CTL epitopes comprising proteasome liberation amino acids or amino acid sequences and, optionally, Transporter Associated with Antigen Processing recognition motifs. The isolated protein is capable of rapidly expanding human cytotoxic T lymphocytes (CTL) in vitro and eliciting a CTL immune response in vivo upon administration to an animal as an exogenous protein. Typically, the isolated protein comprises no more than twenty (20) CTL epitopes derived from cytomegalovirus and/or Epstein-Barr virus antigens.
A protein comprising amino acid sequences of a plurality of CTL epitopes, wherein at least two of the CTL epitopes are separated by a sequence consisting of an intervening amino acid sequence, wherein the intervening amino acid sequence is a one or two amino acid sequence that comprises a proteasome liberation amino acid sequence selected from AD, K and R, and wherein the protein is capable of eliciting a cytotoxic T-lymphocyte immune response upon administration to an animal as an exogenous protein.
A protein comprising amino acid sequences of a plurality of CTL epitopes, wherein each of the CTL epitopes are separated by a sequence consisting of an intervening amino acid sequence, wherein the intervening amino acid sequence is a one or two amino acid sequence comprising a proteasome liberation amino acid sequence selected from AD, K and R, and wherein the protein is capable of eliciting a cytotoxic T-lymphocyte immune response upon administration to an animal as an exogenous protein.
Dependencies are inferred from the claim text.