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AssigneeNovavax, Inc.
InventorsSarathi Boddapati, Anushree Herwadkar, Jason Wong, Yen-Huei Lin, Gale Smith, Jing-Hui Tian
Estimating the term…
Disclosed herein are multivalent nanoparticle vaccine compositions suitable for use in influenza vaccines. The nanoparticles include effective amounts of influenza glycoproteins that provide increased immune responses compared to a commercially available influenza vaccine composition. The present disclosure also provides vaccine formulation strategies that are cost effective and are convenient for clinical use. Methods of administering the nanoparticle vaccine compositions to a subject are also disclosed.
A composition comprising:
A method of preparing a HaSMaN comprising combining a detergent core nanoparticle containing hemagglutinin (HA) with an ISCOM matrix particle for at least about four hours,
A method of preparing a HaSMaN comprising combining a detergent core nanoparticle containing hemagglutinin (HA) with an ISCOM matrix particle for at least about four hours,
Dependencies are inferred from the claim text.