Influenza virus vaccine and method of making
AssigneeMississippi State University
InventorsXiu-Feng Wan, Feng Wang
Life of this patent
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Abstract
A composition for increasing vaccine yields due to increased virus growth in mutation comprising a vaccine strain bearing the Y161F mutation in hemagglutinin (HA). Y161F in HA increases HA thermostability without changing its original antigenic properties and enhances its binding affinity in the vaccine production platforms used in influenza vaccine manufacturing. A method for optimizing preparation of influenza vaccine seed strains which can further lower the cost of vaccines and increase profits for the vaccine companies, and also maintain antigenic stability during vaccine deliveries.
Claims4
The method of using Y161F mutation in hemagglutinin to generate seed virus of high yield for influenza vaccine development and production, comprising using site-directed mutagenesis to create mutation Y161F in hemagglutinin of influenza virus.
Dependencies are inferred from the claim text.