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US 11,896,653 B2Granted
Silicified cell replicas, methods of making, and methods of using
AssigneeUNM Rainforest Innovations
InventorsRita E. Serda, C. Jeffrey Brinker, Jacob Ongudi Agola, Jimin Guo, Sarah Adams
Life of this patent
Estimating the term…
Abstract
A silicified cell replica includes a silicified cell or a silicified subcellular fragment. The silicified cell replica may be used to induce an immunological response, treat a bacterial infection, or treat a patient with cancer.
Claims20
A pharmaceutical composition comprising:
- a silicified cell, a silicified cell-derived body, or a silicified vesicle;
- and
- a pharmaceutically acceptable adjuvant.
A method of inducing an immune response against an antigen, the method comprising:
- obtaining a cell that expresses the antigen;
- silicifying the cell;
- and
- administering to a subject a composition comprising:
- the silicified cell;
- and
- a pharmaceutically acceptable adjuvant, the composition administered in an amount effective to induce the subject to produce an immune response directed against the antigen.
4 more elements
A method for treating a subject having, or at risk of having, a bacterial infection, the method comprising:
- obtaining a bacterial cell that the subject is, or is at risk, of being infected by;
- silicifying the bacterial cell;
- and
- administering to the subject a composition comprising:
- the silicified cell;
- and
- a pharmaceutically acceptable adjuvant, the composition administered in an amount effective to ameliorate at least one symptom or clinical sign of infection by the bacterial cell.
4 more elements
A method for treating a subject having, or at risk of having, a tumor, the method comprising:
- obtaining a tumor cell that the subject has or is at risk of having;
- silicifying the tumor cell;
- and
- administering to the subject a composition comprising:
- the silicified tumor cell;
- and
- a pharmaceutically acceptable adjuvant, the composition administered in an amount effective to ameliorate at least one symptom or clinical sign of having the tumor.
4 more elements
Dependencies are inferred from the claim text.