Methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction
AssigneesInstitut National de la Sante et de la Recherche Medicale, Universite Paul Sabatier Toulouse III, Centre Hospitalier Universitaire De Toulouse
InventorsPhilippe Valet, Cedric Dray, Vincent Minville, Bernard Frances, Francois Labaste, Claire Vinel
Life of this patent
Estimating the term…
Abstract
The present invention relates to methods and pharmaceutical compositions for the treatment of post-operative cognitive dysfunction. In particular, the present invention relates to a method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an APJ receptor agonist.
Claims13
A method of treating post-operative cognitive dysfunction in a subject in need thereof comprising administering to the subject at least one dose of a therapeutically effective amount of an APJ receptor agonist, wherein the APJ receptor agonist is apelin-13;
- wherein the cognitive impairment is measured prior to and/or following the surgery by performing at least one neuropsychological test to test a function selected from the group consisting of verbal comprehension, perceptual organization, executive function, abstraction, problem solving, cognitive flexibility, visual tracking, game performance, psychomotor performance, psychomotor speed, digital symbol substitution, processing speed, dot-connection, flicker-fusion, simple reaction time, choice reaction time and perceptive accuracy;
- wherein the at least one dose of the therapeutically effective amount of the APJ receptor agonist is administered within six hours prior to administration of an anesthetic and/or within six hours following administration of an anesthetic;
- wherein the route of administration is selected from the group consisting of oral, implant, subcutaneous, transdermal, topical, intraperitoneal, intramuscular, intravenous, subdermal, transdermal, intranasal and rectal;
- and
- wherein the therapeutically effective amount of the APJ receptor agonist is sufficient to reduce or ameliorate the cognitive impairment caused by surgery.
A method of treating or inhibiting post-operative cognitive dysfunction in a subject in need thereof, comprising
- administering to the subject at least one dose of a therapeutically effective amount of an APJ receptor agonist, wherein the APJ receptor agonist is apelin-13;
- wherein the at least one dose of the therapeutically effective amount of the APJ receptor agonist is sufficient to reduce or ameliorate a cognitive impairment of memory, attention, learning and/or speed of information processing caused by an anesthetic administered for a surgery;
- wherein the cognitive impairment is measured prior to and/or following the surgery by performing at least one neuropsychological test to test a function selected from the group consisting of verbal comprehension, perceptual organization, executive function, abstraction, problem solving, cognitive flexibility, visual tracking, game performance, psychomotor performance, psychomotor speed, digital symbol substitution, processing speed, dot-connection, flicker-fusion, simple reaction time, choice reaction time and perceptive accuracy,
- wherein the at least one dose is administered within six hours prior to and/or within six hours following administration of the anesthetic;
- and
- wherein the route of administration is selected from the group consisting of oral, implant, subcutaneous, transdermal, topical, intraperitoneal, intramuscular, intravenous, subdermal, transdermal, intranasal and rectal.
Dependencies are inferred from the claim text.