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US 11,896,645 B2Granted
Compounds for use in the treatment of telomere related diseases and/or telomere related medical conditions
AssigneeUniversity of the Witwatersrand, Johannesburg
InventorsStefan Franz Thomas Weiss, Boitelo Theresiah Letsolo, Kerrilyn Naidoo, Tyrone Chad Otgaar
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Abstract
The invention relates to compounds for use in the treatment of telomere related diseases and/or telomere related medical conditions, particularly wherein said telomere related diseases and/or telomere related medical conditions are cancer and cellular ageing. Particularly, herein is disclosed 37 kDa/67 kDa laminin receptor precursor/high affinity laminin receptor (LRP/LR) and/or a fragment thereof for use in the treatment and/or prevention of cellular ageing.
Claims6
A method comprising:
- (a) transfecting a cell with a transfecting agent and (b) producing within the cell a 37 kDa/67 kDa laminin receptor precursor/high affinity laminin receptor (LRP/LR) comprising the amino acid sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2;
- wherein the level of human telomerase reverse transcription, telomerase activity, and/or telomere length is increased;
- and wherein the level of a senescent marker is decreased.
2 more elements
Dependencies are inferred from the claim text.