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US 11,896,642 B2Granted
Bioconjugates with chemically modified backbones
AssigneeSymic Holdings, Inc.
InventorsJohn Eric Paderi, Glenn Prestwich, Katherine Allison Stuart, Harsha Kabra, Elvis Ikwa
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Abstract
Provided herein are synthetic bioconjugates comprising collagen-binding peptides covalently bound to chemically modified glycan backbones, compositions containing the same, and uses thereof.
Claims8
A bioconjugate comprising at least one peptide(s), wherein the at least one peptide(s) comprises a collagen-binding unit covalently bonded to a chemically sulfated hyaluronic acid,
- wherein the chemically sulfated hyaluronic acid has a molecular weight greater than about 150 kDa,
- wherein the chemically sulfated hyaluronic acid comprises from 15 to 30 percent (%) functionalization with peptides,
- wherein the chemically sulfated hyaluronic acid has been chemically sulfated to a degree of sulfation of from about 2.0 to about 3.0, and
- wherein the at least one peptide(s) comprises the amino acid sequence of SEQ ID NO:
- 17.
2 more elements
Dependencies are inferred from the claim text.