Visco-supplement compositions, and methods of use thereof

A method of lubricating a joint in a subject in need thereof, the method comprising:

• injecting into an intra-articular space of the joint a visco-supplement composition including a processed transcellular fluid, wherein the processed transcellular fluid includes,
• (a) an increased concentration of at least three of a first component selected from the group consisting of 30.25 g/L to 50.375 g/L of proteins, 0.003 g/L to 0.3 g/L of phospholipids, 0.25 g/L to 6.5 g/L of fatty acids, 0.5 g/L to 9.5 g/L of cholesterol, glucose at a concentration of 600 mg/L to 900 mg/L, fructose at a concentration of 48 mg/L to 59 mg/L, hyaluronic acid at a concentration of 30 μg/L to 3600 μg/L, and lubricin at a concentration of 10 μg/ml to 200 μg/ml, as compared to a concentration in an unprocessed transcellular fluid;
• and
• (b) a decreased concentration of at least two of a second component selected from the group consisting of no more than 160 mg/L of urea, no more than 80 g/L of uric acid, and no more than 14 mg/L of creatinine, as compared to a concentration in the unprocessed transcellular fluid.