Methods of producing pancreatic hormones
AssigneeViaCyte, Inc.
InventorsLaura Martinson, Evert Kroon, Kevin D'Amour, Emmanuel Edward Baetge
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Abstract
Disclosed herein are methods of producing pancreatic hormone-expressing cells by first differentiating pluripotent cells in cell culture so as to produce endodermal cells, the endodermal cells being competent to further differentiate into hormone-expressing cells capable of secreting at least one pancreatic hormone in response to a physiological signal, and then, transplanting the cultured endodermal cells into an organism, such as an organism in need of an endocrine cell therapy.
Claims14
A method for producing insulin in a human subject in need thereof, comprising:
- maturing in vivo a cell population comprising human PDX-1 positive pancreatic cells that has been transplanted into the human subject,
- thereby obtaining insulin secreting cells that secrete insulin in response to glucose stimulation, and producing insulin in the human subject.
A method for producing insulin in a human in need thereof, said method comprising the steps of:
- a) transplanting a cell population comprising a population of human PDX-1 positive pancreatic cells into the human;
- and
- b) maturing in vivo the transplanted human PDX-1 positive pancreatic cells of step a) in the human,
- thereby obtaining insulin secreting cells that secrete insulin in response to glucose stimulation and producing insulin in the human.
Dependencies are inferred from the claim text.