Engineered immune cell and use thereof
AssigneeBioheng Therapeutics Limited
InventorsYun Xing, Zhonghui Yan, Ying Xiong, Rongrong Pu, Jiangtao Ren, Xiaohong He, Yanbin Wang, Lu Han
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Abstract
An engineered immune cell, which expresses (i) a cell surface molecule that specifically recognizes a ligand, (ii) an exogenous interleukin, and (iii) an exogenous Flt3L, XCL2, and/or XCL1; the engineered immune cell can be used for treating cancer, infection, or autoimmune diseases; and compared with a traditional engineered immune cell, the engineered immune cell has significantly improved tumor killing activity.
Claims22
An engineered immune cell, which expresses (i) a cell surface molecule that specifically recognizes a ligand, (ii) an exogenous IL-7, and (iii) an exogenous XCL2 and/or XCL1 gene.
A nucleic acid molecule, which contains:
- (i) a nucleic acid sequence encoding a cell surface molecule that specifically recognizes a ligand, (ii) a nucleic acid sequence encoding an IL-7, and (iii) a nucleic acid sequence encoding XCL2 and/or XCL1.
Dependencies are inferred from the claim text.