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US 11,896,618 B2Granted
FLT3L-based chimeric proteins
AssigneeShattuck Labs, Inc.
InventorsTaylor Schreiber, George Fromm, Suresh De Silva
Life of this patent
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Abstract
The present invention relates, inter alia, to compositions and methods, including chimeric proteins comprising an extracellular domain of FMS like tyrosine kinase 3 ligand (FLT3L) and an extracellular domain of a Type II transmembrane protein that find use in the treatment of disease, such as cancer.
Claims3
A chimeric protein of a general structure of:
- N terminus-(a)-(b)-(c)-C terminus,
- wherein:
- (a) is a first domain comprising the extracellular domain of FMS like tyrosine kinase 3 ligand (FLT3L),
- (b) is a linker adjoining the first domain and a second domain, and
- (c) is the second domain comprising the extracellular domain of 4-1 BB ligand (4-1 BBL).
2 more elements
Dependencies are inferred from the claim text.