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US 11,896,605 B2Granted
Composition comprising HMSs/HMOs and use thereof
AssigneeGlycom A/S
InventorsLouise Kristine Vigsnæs, Bruce McConnell, Emma Elison
Life of this patent
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Abstract
This disclosure relates generally to compositions and methods for preventing or treating mast cell mediated visceral pain.
Claims13
A method for reducing mast cell mediated visceral hypersensitivity and/or pain in a non-infant human, the method comprising:
- selecting an effective amount of one or more neutral human milk oligosaccharides (HMOs) selected from the group consisting of 2′-fucosyllactose (2′-FL), 3-fucosyllactose (3-FL), difucosyllactose (DFL), lacto-N-fucopentaose I, lacto-N-tetraose (LNT), lacto-N-neotetraose (LNnT), and combinations thereof, the amount effective for increasing a relative abundance of Bifidobacterium adolescentis in the gastrointestinal microbiota of the non-infant human;
- and
- increasing the relative abundance of Bifidobacterium adolescentis in the gastrointestinal microbiota of the non-infant human and reducing the mast cell mediated visceral hypersensitivity and/or pain by administering to the non-infant human a daily dose of from about 3 g to about 10 g of the one or more HMOs.
A method for reducing mast cell mediated visceral hypersensitivity and/or mast cell mediated visceral pain in a non-infant human, the method comprising:
- selecting an effective amount of one or more neutral human milk oligosaccharides (HMOs) selected from the group consisting of 2′-fucosyllactose (2′-FL), 3-fucosyllactose (3-FL), difucosyllactose (DFL), lacto-N-fucopentaose I, lacto-N-tetraose (LNT), lacto-N-neotetraose (LNnT), and combinations thereof, the amount effective for increasing a relative abundance of Bifidobacterium adolescentis in the gastrointestinal microbiota of the non-infant human;
- increasing the relative abundance of Bifidobacterium adolescentis in the gastrointestinal microbiota of the non-infant human and reducing the mast cell mediated visceral hypersensitivity and/or pain by administering to the non-infant human a daily dose of from about 3 g to about 10 g of the one or more neutral HMOs;
- and
- selectively increasing expression of intestinal goblet cell genes to improve mucosal barrier function in gastrointestinal tract of the non-infant human by administering to the non-infant human the daily dose of the one or more neutral HMOs.
1 more element
Dependencies are inferred from the claim text.