Modified release preparations containing oxcarbazepine and derivatives thereof
AssigneeSupernus Pharmaceuticals, Inc.
InventorsPadmanabh P. Bhatt, Argaw Kidane, Kevin Edwards
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Abstract
Controlled-release preparations of oxcarbazepine and derivatives thereof for once-a-day administration are disclosed. The inventive compositions comprise solubility- and/or release enhancing agents to provide tailored drug release profiles, preferably sigmoidal release profiles. Methods of treatment comprising the inventive compositions are also disclosed.
Claims20
A pharmaceutical controlled release formulation comprising a homogeneous matrix, which comprises (a) oxcarbazepine, (b) a matrix-forming polymer selected from the group consisting of cellulosic polymers, alginates, gums, cross-linked polyacrylic acid, carageenan, polyvinyl pyrrolidone, polyethylene oxides, and polyvinyl alcohol, and (c) at least one agent that enhances the solubility of oxcarbazepine.
Dependencies are inferred from the claim text.