ErbB/BTK inhibitors
AssigneeDizal (Jiangsu) Pharmaceutical Co., Ltd.
InventorsZhenfan Yang, Xiaolin Zhang
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Abstract
Disclosed are compounds inhibiting ErbBs (e.g., EGFR or Her 2), especially mutant forms of ErbBs, and BTK, pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat ErbBs (especially mutant forms of ErbBs) or BTK associated diseases, including cancer.
Claims20
A method of treating an ErbB associated disease in a subject, comprising administering to the subject about 50 mg to about 500 mg per day of (R)—N-(5-(4-(5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenylamino)pyrimidin-2-ylamino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide, or a pharmaceutically acceptable salt, hydrate, solvate or stereoisomer thereof, wherein the ErbB associated disease is lung cancer.
A pharmaceutical composition formulated in a unit-dosage form comprising about 50 mg-about 500 mg (R)—N-(5-(4-(5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenylamino)pyrimidin-2-ylamino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide, or a pharmaceutically acceptable salt, hydrate, solvate or stereoisomer thereof.
A pharmaceutical composition comprising about 50 mg-about 500 mg (R)—N-(5-(4-(5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)phenylamino)pyrimidin-2-ylamino)-2-(3-(dimethylamino)pyrrolidin-1-yl)-4-methoxyphenyl)acrylamide, or a pharmaceutically acceptable salt, hydrate, solvate or stereoisomer thereof.
Dependencies are inferred from the claim text.