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US 11,896,568 B2Granted
Compositions and methods for treating patients suffering from glioma or leukemia
AssigneeUniversity of Cincinnati
InventorsJianjun Chen, Rui Su
Life of this patent
Estimating the term…
Abstract
Pharmaceutical compositions, kits and methods for treating tumors such as glioma and cancers such as leukemia with (R)-2-hydroxyglutarate (R-2HG) are provided, along with therapeutic regimens including treatment of a patient suffering from glioma or leukemia with a MYC-signaling inhibitor followed by or cotemporaneous with treatment with R-2HG, and optionally other chemotherapeutic agents.
Claims4
A method of treating leukemia in a subject in need thereof, the method comprising administering to the subject a combination of:
- an effective amount of R-2HG;
- and
- one or more chemotherapeutic agents selected from the group consisting of all trans retinoic acid (ATRA), azacitidine (AZA), daunorubicin, and decitabine.
Dependencies are inferred from the claim text.