Tissue removal devices, systems and methods

A tissue removal device for removal of tissue from an eye during surgery, comprising:

• a hollow needle comprising an open distal tip;
• an aspiration line communicating with the hollow needle and configured for communicating with a vacuum source, wherein the hollow needle and the aspiration line define an aspiration path from the distal tip to the vacuum source;
• a vacuum device configured for controlling a vacuum at the distal tip;
• a first collection chamber connected to the aspiration line;
• a second collection chamber a valve connected between the first collection chamber and the second collection chamber;
• a vacuum regulator configured to control vacuum levels in the first collection chamber and the second collection chamber applied by the vacuum device, wherein the vacuum regulator applies vacuum only to the first collection chamber in a first tissue collection state for tissue collection only in the first collection chamber, and wherein the vacuum regular applies vacuum to both the first and second collection chambers in a second tissue collection states for tissue collection in both the first and second collection chambers;
• and
• a restrictor at the distal tip of the hollow needle, the restrictor having an inner diameter smaller than an inner diameter of the hollow needle.