Reinforced bone scaffold
AssigneeMarquette University
InventorsLobat Tayebi, Morteza Rasoulianboroujeni
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Abstract
Scaffolds for use in bone tissue engineering include a skeleton and a host component. Methods of preparation of scaffolds include identification of biodegradation properties for the skeleton and the host component. The skeleton is constructed to form a three-dimensional shape. The skeleton is constructed of a first material and has a first rate of biodegradation. The host component fills the three-dimensional shape formed by the skeleton. The host component is constructed of a second material and has a second rate of biodegradation. The first rate of biodegradation is slower than the second rate of biodegradation.
Claims16
A method of preparing a scaffold for use in bone tissue engineering, the method comprising:
- obtaining a 3D model of a treatment area of a patient;
- determining a degradability of the scaffold based upon the patient and treatment area;
- selecting a first porosity of a skeleton and a first rate of biodegradation of the skeleton;
- selecting a second porosity of a host component and a second rate of biodegradation of the host component to achieve the degradability;
- digitally designing a skeleton to fit the treatment area;
- manufacturing the skeleton with a material having the first porosity and first rate of biodegradation to form a three-dimensional shape defining a space;
- and
- filling the space defined by the skeleton with the host component having the second porosity and the second rate of biodegradation, wherein the first porosity is smaller than the second porosity and the first rate of biodegradation is slower than the second rate of biodegradation.
Dependencies are inferred from the claim text.