Animal models of corneal ectatic diseases, methods of producing, and methods of use thereof
OwnerArturo Solis Herrerainventor
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Abstract
Methods of producing non-human animal models of corneal ectatic diseases, such as corneal keratoconus, by applying an aromatic compound to the eye of a non-human animal are described. Also described are non-human animal models of corneal ectatic diseases, and methods of using the non-human animal models to screen compounds that modulate corneal ectatic diseases.
Claims8
A method of producing a non-human animal model of a corneal ectatic disease, the method comprising applying to a cornea of at least one eye of a non-human animal an effective amount of an aromatic compound selected from the group consisting of benzene and phenol, wherein the effective amount of benzene applied is 70 μmol to 85 μmol and the effective amount of phenol applied is 30 μmol to 70 μmol.
A method of screening compounds to modulate a corneal ectatic disease, the method comprising:
- (i) preparing a non-human animal model of a corneal ectatic disease by a method comprising applying to a cornea of at least one eye of a non-human animal an effective amount of an aromatic compound selected from the group consisting of benzene and phenol, wherein the effective amount of benzene applied is 70 μmol to 85 μmol and the effective amount of phenol applied is 30 μmol to 70 μmol;
- (ii) administering a test compound to the at least one eye of the non-human animal model;
- and
- (iii) determining an effect of the test compound on structural distortion of the cornea.
Dependencies are inferred from the claim text.