Genetically modified rat models for severe combined immunodeficiency (SCID)
AssigneeHera Testing Laboratories, Inc.
InventorsEric M. Ostertag, John Stuart Crawford, Joseph Ruiz
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Abstract
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In another aspect, the invention relates to genetically modified rats, as well as the descendants and ancestors of such animals, which are animal models of human cancer and methods of their use.
Claims21
A genetically engineered rat, or progeny of the rat, whose genome comprises a homozygous knock-out of the interleukin 2 receptor subunit gamma (Il2rg) gene and a homozygous knock-out of the recombination activating gene 1 (Rag 1) gene, wherein the rat or its progeny exhibits Severe Combined Immunodeficiency (SCID), wherein the rat or its progeny has decreased levels of mature T-cells, B-cells and NK-cells, as compared to a rat not comprising the knock-out of the Il2rg gene and the knock-out of the Rag1 gene.
Dependencies are inferred from the claim text.