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US 11,839,642 B2Granted
Anti-angiogenin peptides, compositions, and methods of use
AssigneeThe Board of Regents of the University of Oklahoma
InventorsChuanbin Mao, Yan Li
Life of this patent
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Abstract
Carrier compositions, including human-safe phages, equipped with one or more angiogenin-binding peptides, and optionally with tumor-homing peptides for use in anti-tumor therapies, are described. The angiogenin-binding peptides bind to and inactivate angiogenin molecules thereby blocking their angiogenic activity thus inhibiting angiogenesis in the tissue in which the compositions are localized.
Claims20
A peptide composition, comprising:
- a peptide linked to a carrier, the peptide comprising an amino acid sequence selected from the group consisting of WPYWNHHSHNNV (SEQ ID NO:1) and FHHPSIHDRHRH (SEQ ID NO:2), and variant sequences thereof, wherein the variant sequence has at least 83% identity with one of SEQ ID NO:1-2.
A method of inhibiting angiogenesis in a subject in a subject in need of such therapy, comprising:
- administering to the subject an effective amount of a peptide composition comprising a peptide linked to a carrier, the peptide comprising an amino acid sequence selected from the group consisting of WPYWNHHSHNNV (SEQ ID NO:1) and FHHPSIHDRHRH (SEQ ID NO:2), and variant sequences thereof, wherein the variant sequence has at least 83% identity with one of SEQ ID NO:1-2.
Dependencies are inferred from the claim text.