Hydrophobically modified chitosan compositions
AssigneeMedcura, Inc.
InventorMatthew Dowling
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Abstract
Disclosed herein is a polymer composition comprising an effective amount of a hydrophobically-modified polymer having functional groups along the backbone occupied by a fatty anhydride moiety. The polymer composition has a potent hemostatic action by gelling blood upon contact, and is suitable for treating internal and external bleeds. As disclosed herein, the modified polymer can be generated without the use of toxic reagents that would require removal from the product. Further, compositions are shelf stable even in a flowable form. That is, the hydrophobic grafts are not lost under product storage conditions (e.g., room temperature storage).
Claims23
A method for treating a wound in a patient, comprising, applying a polymer composition comprising an effective amount of a hydrophobically-modified chitosan having hydrocarbon groups attached to the chitosan backbone through amide linkages to a wound, wherein the composition is formulated with a pH of about 5 or less, wherein the hydrocarbon groups comprise C8 to C18 hydrocarbon groups in an effective amount to form an artificial clot in the presence of blood.
Dependencies are inferred from the claim text.