MUC16 monoclonal antibody and uses thereof
AssigneeQuest Pharmatech Inc.
InventorsRagupathy Madiyalakan, Michael Hollingsworth, Prakash Radhakrishnan
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Abstract
The present document describes an antibody or an antigen-binding fragment that bind to O-glycan mucin-type glycoprotein MUC16 comprising three variable heavy domain complementarity determining regions (CDR)(CDR H1, H2 and H3), and three variable lighy domain CDR (CDR L1, L2 and L3). The present invention also relates to pharmaceutical compositions, nucleic acid vectors, cells comprising the nucleic acid vectors, and methods of inhibiting tumor growth of a tumor expressing O-glycan mucin-type glycoprotein MUC16.
Claims18
An antibody or an antigen-binding fragment thereof that binds to O-glycan mucin-type glycoprotein MUC16, comprising three variable heavy domain complementarity determining regions (CDR) (CDR H1, H2, and H3), and three variable light domain CDR (CDR L1, L2, and L3), wherein the CDR H1, H2, H3, L1, L2, and L3 comprise the amino acid sequence:
- CDR H1:
- (SEQ ID NO:
- 1)
- GFTFSTF,
- CDR H2:
- (SEQ ID NO:
- 2)
- SSGSST,
- CDR H3:
- (SEQ ID NO:
- 3)
- SGYDYDPIYYALDY,
- CDR L1:
- (SEQ ID NO:
- 4)
- RASESVDNYGISFMN,
- CDR L2:
- (SEQ ID NO:
- 5)
- GASNQGS,
- and
- CDR L3:
- (SEQ ID NO:
- 6)
- QQTKEVPWT.
Dependencies are inferred from the claim text.