Preparation comprising vonoprazan
AssigneeTakeda Pharmaceutical Company Limited
InventorsHiroyuki Fujii, Akira Suzuki
Life of this patent
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Abstract
The present invention aims to provide a preparation expected to improve the bitter taste of an organic acid salt of vonoprazan and permit rapid dissolution of the organic acid salt of vonoprazan after administration. The present invention provides a preparation containing fine granules or granules containing (1) a core granule containing an organic acid salt of vonoprazan, (2) an intermediate layer containing the same organic acid as the organic acid forming the salt of vonoprazan in (1), or a salt thereof, and (3) a coating layer containing a water-insoluble polymer.
Claims16
A preparation comprising fine granules or granules comprising
- (1) a core granule containing an organic acid salt of vonoprazan,
- (2) an intermediate layer containing the same organic acid as the organic acid forming the salt of vonoprazan in (1), or a salt thereof, and
- (3) a coating layer containing a water-insoluble polymer,
- wherein the organic acid salt of vonoprazan is vonoprazan fumarate, the organic acid or a salt thereof in said (2) is fumaric acid or a salt of fumaric acid.
Dependencies are inferred from the claim text.