In vivo immunoimaging of interferon-gamma
AssigneeWayne State University
InventorsNerissa Viola, Heather Gibson
Life of this patent
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Abstract
Methods for in vivo immunoimaging including: (a) administering a labeled-antibody conjugate to a subject, wherein the labeled-antibody conjugate includes: an antibody that specifically recognizes and binds to IFN-γ, and a detection label conjugated to the antibody, wherein the detection label is a radionuclide tracer or tluorophore; and (b) detecting the presence of the radiolabeled-antibody conjugate in the subject in vivo by imaging. Embodiments of the present disclosure are directed to labeled-antibody conjugates and therapeutic radionuclide-antibody conjugates.
Claims11
A method for in vivo immunoimaging interferon gamma (IFN-γ) as a marker of active T cells in a subject with cancer, comprising:
- administering a labeled-antibody conjugate to a subject, wherein the labeled-antibody conjugate comprises:
- an antibody that specifically binds to IFN-γ, and
- a detection label conjugated to the antibody, wherein the detection label is a radionuclide tracer selected from 11C, 13N, 15O, 18F, 44Sc, 45Ti, 52Mn, 64Cu, 68Ga, 76Br, 82Rb, 86Y, 89Zr, 111In, 124I, 43K, 52Fe, 57Co, 67Cu, 67Ga, 77Br, 81Rb, 81mKr, 87mSr, 113mIn, 123I, 127Cs, 129Cs, 132I, 197Hg, 203Pb, 206Bi, or a combination of any two or more thereof;
- and
- detecting the presence of the labeled-antibody conjugate in the subject in vivo by imaging, wherein specific binding of the labeled-antibody conjugate to IFN-γ indicates the presence of activated T cells.
Dependencies are inferred from the claim text.