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US 11,661,586 B2Granted
Extracellular redox enzyme system to alleviate disease
AssigneeThe General Hospital Corporation
InventorsVamsi K. Mootha, Xiaoyan Robert Bao, Anupam Patgiri
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Abstract
Compositions comprising (i) lactate oxidase (LOX) and Catalase (CAT), preferably in a 1:1 molar ratio; or (ii) a fusion polypeptide comprising both LOX and CAT, e.g., LOXCAT, and methods of use thereof for reducing blood lactate levels, increasing blood pyruvate levels, and/or decreasing blood lactate/pyruvate ratio in a subject.
Claims11
A method of reducing blood lactate levels, increasing blood pyruvate levels, and/or decreasing blood lactate/pyruvate ratio in a subject, the method comprising administering to the subject a therapeutically effective amount of:
- (i) lactate oxidase (LOX) and Catalase (CAT);
- or
- (ii) a fusion polypeptide comprising both LOX and CAT.
Dependencies are inferred from the claim text.