Mini-tablets
AssigneeDfe Pharma GmbH & Co. KG
InventorsKorinde Van Den Heuvel, Bas Van Laarhoven, Eva Maria Janssen, Mara Maria Wilhelmina Van Haandel
Life of this patent
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Abstract
The invention relates to a method for making a tablet having a diameter, as determined by the longest enveloping circle, in the range of 1 to 5 mm and/or a weight in the range of 1 to 100 mg—comprising an active ingredient selected from the group of pharmaceutical substances and active substances for a dietary supplement or nutraceutical, comprising (a) providing a lactose agglomerate comprising lactose, and a sugar alcohol; (b) providing the active ingredient; (c) mixing the agglomerate and the active ingredient, thereby obtaining a mixture; and (d) forming the tablet by direct compression.
Claims19
A method for making a tablet having a diameter, as determined by the longest enveloping circle, in the range of 1 to 5 mm and/or a weight in the range of 1 to 100 mg, the method comprising:
- (a) agglomerating in a fluidized bed anhydrous lactose particles with an aqueous binding solution comprising (i) a sugar alcohol selected from the group consisting of lactitol, maltitol, sorbitol, mannitol and erythritol, and (ii) a water soluble carbohydrate comprising alpha-lactose monohydrate, thereby forming agglomerates of the lactose particles, wherein the binding solution is used in an amount of 0.05-0.25 kg dry solids in the binding solution per kg lactose agglomerate, and wherein the agglomerates comprise 80-99 wt. % anhydrous lactose and have a size, as determinable by sieving, of 600 μm or less;
- (b) mixing the agglomerates with an active ingredient, and optionally one or more excipients, thereby obtaining a mixture;
- and
- (d) forming the mixture into the tablet by direct compression.
A method for preparing a lactose agglomerate filler in the manufacture of tablets, comprising:
- agglomerating in a fluidized bed anhydrous lactose particles with an aqueous binding solution comprising (i) a sugar alcohol selected from the group consisting of lactitol, maltitol, sorbitol, mannitol and erythritol, and (ii) a water soluble carbohydrate comprising alpha-lactose monohydrate, thereby forming agglomerates of the lactose particles, wherein the binding solution is used in an amount of 0.05-0.25 kg dry solids in the binding solution per kg lactose agglomerate,
- wherein the agglomerates comprise 80-99 wt. % anhydrous lactose and have a size, as determinable by sieving, of 600 μm or less.
Dependencies are inferred from the claim text.