Devices and methods for light delivery

A conformable light delivery device for increasing light penetration depth into a tissue, comprising:

• a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member;
• and
• a substrate that supports the tissue penetrating members,
• wherein the microarray of tissue penetrating members is formed from a microarray material having an index of refraction that is matched to an index of refraction of the substrate;
• and
• wherein the tissue penetrating members have an effective Young's modulus selected to withstand stresses during insertion through a tissue surface without substantial deformation in a direction that decreases the penetration depth into the tissue.

A conformable light delivery device for increasing light penetration depth in a tissue, comprising:

• a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member;
• a substrate that supports the tissue penetrating members, wherein the microarray of tissue penetrating members is formed from a microarray material having an index of refraction that is matched to an index of refraction of the substrate;
• and
• a bioactive agent releasably connected to the microarray of tissue penetrating members, wherein the bioactive agent is activated by light transmitted by the microarray of tissue penetrating members.

A conformable light delivery device for increasing light penetration depth in a tissue, comprising:

• a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member;
• a substrate that supports the tissue penetrating members, wherein the microarray of tissue penetrating members is formed from a microarray material having an index of refraction that is matched to an index of refraction of the substrate;
• and
• a light intensity modulator for controlling light intensity as a function of depth from a tissue surface, wherein the light intensity modulator comprises a non-transparent coating extending from the tissue penetrating members' proximal end to reduce optical light intensity to a tissue surface region.

A conformable light delivery device for increasing light penetration depth in a tissue, comprising:

• a microarray of tissue penetrating members, each member having a distal end and a proximal end, wherein the tissue penetrating members are at least partially optically transparent to provide optical transmission through a surface that extends between the distal and proximal ends of each tissue penetrating member;
• and
• a substrate that supports the tissue penetrating members,
• wherein the microarray of tissue penetrating members is formed from a microarray material having an index of refraction that is matched to an index of refraction of the substrate;
• and
• wherein the substrate further comprises a substrate component that improves light delivery, wherein the substrate component comprises one or more of glycerol or perfluorodecalin.

An injectable therapeutic light delivery device comprising:

• a substrate;
• a tissue penetrating member having a proximal end and a distal end, wherein the proximal end is supported by the substrate;
• a plurality of light sources optically dispersed along a member wall that extends between the member proximal and distal ends;
• and
• a light intensity modulator for controlling light intensity of the plurality of light sources as a function of depth from a tissue surface, wherein the light intensity modulator comprises a non-transparent coating extending from the tissue penetrating members' proximal end to reduce optical light intensity to a tissue surface region;
• wherein the tissue penetrating member and the plurality of light sources are configured to penetrate a tissue to provide controlled subsurface light intensity to the tissue that surrounds the tissue penetrating member during use.