Atlas registration for resting state network mapping in patients with brain tumors
AssigneeWashington University
InventorsKi Yun Park, Abraham Snyder, Eric Leuthardt
Life of this patent
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Abstract
A method for mapping brain function of a subject includes generating a lesion mask using a search light algorithm based on a plurality of anatomical images of the subject. The plurality of anatomical images are registered with atlas images by nonlinear atlas registration using the generated lesion mask to generate a warping map. A plurality of functional images of the subject are resampled using the warping map to generate a functional map, functional connectivity is computed using the functional map and a multi-layer perceptron.
Claims20
A method for mapping brain function of a subject, the method comprising:
- receiving a plurality of functional images of a brain of the subject ascertained during a resting state;
- receiving a plurality of anatomical images of the brain of the subject;
- defining one or more regions in the plurality of anatomical images to be excluded from atlas registration of the plurality of anatomical images;
- registering the plurality of anatomical images with atlas images by nonlinear atlas registration with the defined one or more regions excluded to generate a warping map;
- registering the plurality of functional images with atlas images using the warping map to guide the registration;
- and
- computing functional connectivity of the brain of the subject using the registered functional images.
A computing device for use in a system for mapping brain function of a subject, the computing device comprising:
- a processor;
- and
- a memory storing instructions that, when executed by the processor, cause the processor to:
- receive a plurality of functional images of a brain of the subject ascertained during a resting state;
- receive a plurality of anatomical images of the brain of the subject;
- define one or more regions in the plurality of anatomical images to be excluded from atlas registration of the plurality of anatomical images;
- register the plurality of anatomical images with atlas images by nonlinear atlas registration with the defined one or more regions excluded to generate a warping map;
- register the plurality of functional images with atlas images using the warping map to guide the registration;
- and
- compute functional connectivity of the brain of the subject using the registered functional images.
A non-transitory computer readable medium comprising instructions that, when executed by at least one processor, cause the processor to:
- receive a plurality of functional images of a brain of the subject;
- receive a plurality of anatomical images of the brain of the subject;
- define one or more regions in the plurality of anatomical images to be excluded from atlas registration of the plurality of anatomical images;
- register the plurality of anatomical images with atlas images by nonlinear atlas registration with the defined one or more regions excluded to generate a warping map;
- register the plurality of functional images with atlas images using the warping map to guide the registration;
- and
- compute functional connectivity of the brain of the subject using the registered functional images.
Dependencies are inferred from the claim text.