US 11,442,059 B2Granted

Method for treating a chronic itch condition by administering small molecule MrgprX4 antagonists

AssigneeThe Johns Hopkins University

InventorsXinzhong Dong, Chirag Vasavda, Solomon H. Snyder, James Meixiong, Yingying Cheng, Nathachit Limjunyawong, Xintong Dong

Life of this patent

Estimating the term…

Abstract

The present invention relates to cells and methods for detecting compounds that affect G protein coupled receptor mediated conditions. The invention also relates to methods for treating adverse drug reactions, autoimmune disorders, and pruritus.

Claims3

Dependent claims

A method for treating a subject suffering from a chronic itch condition, comprising:

administering to the subject a small molecule MrgprX4 antagonist.

Dependencies are inferred from the claim text.

Facts

Application: 16/623,279Filed 15 Jun 2018 · us provisional application
Priority: 16 Jun 2017
Published: US 2020/0173985 A14 Jun 2020
Granted: 13 Sep 2022
Term ends: Not estimatedThe source records don’t support an estimate.

Classification12 codes

G01N 33/5041
For testing non-proliferative effects: involving analysis of members of signalling pathways
C07K 14/705
From animals; from humans: receptors; Cell surface antigens; Cell surface determinants
C07K 14/723
For hormones: g protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
C12N 15/63
Recombinant DNA-technology: introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Family

Application62/520,812Us provisional application · filed 16 Jun 2017
US 2020/0173985 A1Pre-grant publication · published 4 Jun 2020
US 11,442,059 B2This patent

From the US filing history. Foreign family members aren’t listed.

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