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US 11,441,987 B2Granted
Systems and methods for analysis of liquids by covered fluidic channels integrated onto sensor platforms
AssigneeDuke University
InventorsZehra Parlak, Stefan Zauscher
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Abstract
Systems and methods for analysis of liquids by covered fluidic channels integrated onto sensor platforms. According to an aspect, a method includes receiving at least one of a liquid and an analyte of interest into a covered fluidic channel with a predetermined orientation. The method also includes confining at least one of the liquid and the analyte of interest within the covered fluidic channel. The method further includes analyzing properties of at least one of the liquid and the analyte of interest.
Claims17
A method comprising:
- providing a characterization device comprising:
- a plurality of covered fluidic channels with a predetermined orientation;
- and
- a sensor platform comprising a non-sensing region and at least one of an active region, a sensitive region, and a central sensing region, wherein the plurality of covered fluidic channels are positioned on a surface of the sensor platform over a portion of the at least one of the active region, the sensitive region, and the central sensing region;
- receiving at least one of a liquid and an analyte of interest into the plurality of covered fluidic channels;
- confining the at least one of the liquid and the analyte of interest within the plurality of covered fluidic channels;
- generating a shear motion on the surface of the sensor platform for application to the at least one of the liquid and the analyte of interest within the plurality of covered fluidic channels;
- and
- analyzing properties of the at least one of the liquid and the analyte interest, wherein analyzing properties comprises analyzing of a mass property of the liquid via a perpendicular orientation of the plurality of covered fluidic channels and/or analyzing a mass property of an analyte attached to a channel surface of the plurality of covered fluidic channels via at least one of the perpendicular orientation and a parallel orientation of the plurality of covered fluidic channels.
6 more elements
A characterization device comprising:
- a plurality of covered fluidic channels with a predetermined orientation;
- a sensor platform comprising a non-sensing region and at least one of an active region, a sensitive region, and a central sensing region, wherein the plurality of covered fluidic channels are positioned on a surface of the sensor platform over a portion of the at least one of the active region, the sensitive region, and the central sensing region;
- an inlet configured to receive at least one of a liquid and an analyte of interest into the covered fluidic channels, wherein the at least one of the liquid and the analyte of interest are confined by the covered fluidic channels;
- a resonator configured to generate a shear motion on the surface of the sensor platform for application to the at least one of the liquid and the analyte of interest within the plurality of covered fluidic channels;
- and
- an analyzer configured to analyze properties of at least one of the liquid and the analyte interest, and
- wherein the predetermined orientation comprises either a perpendicular orientation to sense a mass property of the liquid, or at least one of a parallel orientation to sense a mass property of an analyte attached to a channel surface of the plurality of covered fluidic channel.
4 more elements
A method comprising:
- fabricating a characterization device comprising:
- a plurality of covered fluidic channels comprising a predetermined width and height with predetermined orientation;
- a sensor platform comprising a non-sensing region and at least one of an active region, a sensitive region, and a central sensing region, wherein the plurality of covered fluidic channels are positioned on a surface of the sensor platform over a portion of the at least one of the active region, the sensitive region, and the central sensing region;
- an inlet configured to receive at least one of a liquid and an analyte of interest into the covered fluidic channels, wherein the at least one of the liquid and the analyte of interest are confined by the covered fluidic channels;
- an adhesion mechanism configured to attach the sensor platform to the plurality of covered fluidic channels;
- a resonator configured to generate a shear motion on the surface of the sensor platform for application to the at least one of the liquid and the analyte of interest within the plurality of covered fluidic channels;
- and
- an analyzer configured to analyze properties of at least one of the liquid and the analyte interest, and
- wherein the orientation comprises either a perpendicular orientation to sense a mass property of the liquid, or a parallel orientation of the covered fluidic channel to sense a mass property of an analyte attached to a channel surface of the plurality of covered fluidic channels.
6 more elements
Dependencies are inferred from the claim text.