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US 11,441,198 B2Granted
Compositions and methods for providing a prognosis for influenza infection
AssigneeVersitech Limited
InventorsKai Wang Kelvin To, Jie Zhou, Johnson Yiu-Nam Lau, Kwok-Yung Yuen
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Abstract
Compositions and methods are described that provide prognostic determination of the severity of influenza infection based on the PDE3A status of an individual. Impaired PDE3A function is associated with severe symptoms on contracting influenza. Specific SNP mutations are identified that are associated with impaired PDE3A function, and primers and kits are provided that permit identification of these SNPs. Such information can also be combined with other patient data.
Claims12
A method of treating influenza in an individual, comprising:
- i) obtaining a sample from the individual;
- ii) determining that the individual carries a PDE3A mutation associated with severe influenza disease,
- wherein the mutation comprises one or more of T at rs7314545, T at rs6487131, and G at rs6487132;
- and
- iii) treating the individual determined to carry the PDE3A mutation(s) with an antiviral compound effective against influenza.
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Dependencies are inferred from the claim text.