Back to results
US 11,441,136 B2Granted
DNase variants
AssigneeNovozymes A/S
InventorsLars Henrik Oestergaard, Lars Giger, Annette Helle Johansen, Lars Beier, Jurgen Carsten Franz Knotzel, Gernot J. Abel, Klaus Gori
Life of this patent
Estimating the term…
Abstract
The present invention relates to polypeptide variants and methods for obtaining variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
Claims10
A DNase variant, which comprises two or more substitutions selected from the group consisting of:
- T1I, T1L, T1V, S13Y, T22P, S25P, S27L, S39P, S42G, S42A, S42T, S57W, S57Y, S57F, S59V, S59I, S59L, V76L, V76I, Q109R, S116D, S116E, T127V, T127I, T127L, S144P, A147H, S167L, S167I, S167V, G175D and G175E, wherein
- the positions correspond to the positions of SEQ ID NO:
- 1 (numbering according to SEQ ID NO:
- 1),
- the variant has a sequence identity to the polypeptide shown in SEQ ID NO:
- 1 or the polypeptide shown in SEQ ID NO:
- 28 of at least 90%, and
- the variant has DNase activity.
5 more elements
Dependencies are inferred from the claim text.