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US 11,441,049 B2Granted
Zwitterionic copolymer coatings and related methods
AssigneeUniversity of Washington
InventorsShaoyi Jiang, Xiaojie Lin, Jonathan Himmelfarb, Buddy D. Ratner
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Abstract
Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-fouling and functionality to surfaces, particularly surfaces of blood-contacting medical devices.
Claims15
A method for inhibiting or preventing leaching of a plasticizer from a surface of a substrate, comprising:
- (a) coating at least a portion of a surface of a substrate with a composition comprising a copolymer to provide a coated surface, the copolymer comprising first repeating units and second repeating units, wherein each of the first repeating units comprises a pendant zwitterionic group, and wherein each of the second repeating units comprises a pendant photoreactive group effective for crosslinking the copolymer on a surface, to provide a coated surface;
- and
- (b) irradiating the coated surface with ultraviolet light effective to crosslink the copolymer on the surface, thereby providing a coated surface effective for inhibiting or preventing leaching of a plasticizer from the surface;
- wherein the copolymer has formula (III):
- wherein
- R1 and R2 are independently —(CH2)xH, where x is an integer from 0 to 20;
- R3 and R4 are independently (CH2)xH, where x is an integer from 0 to 20;
- X is O or NH;
- Y is O or NH;
- n is an integer from 1 to 20;
- m is an integer from 1 to 20;
- a is from about 0.10 to about 0.90 mole percent;
- b is about 0.10 to about 0.90 mole percent;
- a+b is 1.0;
- and
- * represents the copolymer terminal groups.
13 more elements
Dependencies are inferred from the claim text.