US 11,440,957 B2Granted

Anti-TMEM106B antibodies and methods of use thereof

AssigneeAlector LLC

InventorsArnon Rosenthal, Eric Brown, Tina Schwabe, Angie Yee, Herve Rhinn

Life of this patent

Estimating the term…

Abstract

The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal antibodies, antibody fragments, etc., that specifically bind a TMEM106B polypeptide, e.g., a mammalian TMEM106B or human TMEM106B, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

Claims43

Dependent claims

An isolated antibody that binds to human TMEM106B, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region and light chain variable region comprise-:

(a) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:4, 37, 80, 122, 162, and 187, respectively;
(b) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:5, 38, 81, 123, 163, and 188, respectively;
(c) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:
11, 44, 87, 123, 169, and 188, respectively;
(d) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:12, 45, 88, 129, 170, and 194, respectively;
(e) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:13, 46, 89, 130, 171, and 195, respectively;
(f) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:14, 47, 90, 131, 170, and 196, respectively;
(g) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:15, 48, 91, 132, 172, and 197, respectively;
(h) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:6, 53, 96, 136, 175, and 201, respectively;
(i) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:14, 54, 97, 137, 176, and 202, respectively;
(j) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:19, 55, 98, 138, 169, and 203, respectively;
(k) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:11, 58, 101, 138, 169, and 207, respectively;
(l) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:14, 64, 107, 146, 161, and 202, respectively;
(m) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:25, 67, 110, 149, 161, and 196, respectively;
(n) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:26, 68, 111, 150, 181, and 214, respectively;
(o) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:27, 69, 112, 151, 181, and 215, respectively;
(p) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:29, 71, 111, 153, 181, and 214, respectively;
(q) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:33, 75, 117, 156, 161, and 220, respectively;
(r) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:9, 42, 85, 127, 167, and 192, respectively;
(s) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:7, 40, 83, 125, 165, and 190, respectively;
(t) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:9, 60, 103, 143, 167, and 192, respectively;
(u) an HVR-H1, HVR-H2, HVR-H3, HVR-11, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:21, 61, 104, 144, 169, and 209, respectively;
(v) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:16, 50, 93, 134, 172, and 199, respectively;
(w) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:13, 46, 89, 141, 171, and 206, respectively;
or
(x) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:22, 62, 105, 145, 161, and 210, respectively.

23 more elements

Dependencies are inferred from the claim text.

Facts

Application: 16/959,081Filed 21 Dec 2018 · us provisional application
Priority: 29 Dec 2017
Published: US 2020/0339680 A129 Oct 2020
Granted: 13 Sep 2022
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07K 16/18
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against material from animals or humans
C07K 16/28
Against material from animals or humans: against receptors, cell surface antigens or cell surface determinants
C07K 2317/33
Characterized by aspects of specificity or valency: crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
C07K 2317/34
Characterized by aspects of specificity or valency: identification of a linear epitope shorter than 20 amino acid residues or of a conformational…

Family

Application62/612,098Us provisional application · filed 29 Dec 2017
US 2020/0339680 A1Pre-grant publication · published 29 Oct 2020
US 11,440,957 B2This patent

From the US filing history. Foreign family members aren’t listed.

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Abstract

(a) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:4, 37, 80, 122, 162, and 187, respectively;
(b) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:5, 38, 81, 123, 163, and 188, respectively;
(c) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:
11, 44, 87, 123, 169, and 188, respectively;
(d) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:12, 45, 88, 129, 170, and 194, respectively;
(e) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:13, 46, 89, 130, 171, and 195, respectively;
(f) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:14, 47, 90, 131, 170, and 196, respectively;
(g) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:15, 48, 91, 132, 172, and 197, respectively;
(h) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:6, 53, 96, 136, 175, and 201, respectively;
(i) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:14, 54, 97, 137, 176, and 202, respectively;
(j) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:19, 55, 98, 138, 169, and 203, respectively;
(k) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:11, 58, 101, 138, 169, and 207, respectively;
(l) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:14, 64, 107, 146, 161, and 202, respectively;
(m) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:25, 67, 110, 149, 161, and 196, respectively;
(n) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:26, 68, 111, 150, 181, and 214, respectively;
(o) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:27, 69, 112, 151, 181, and 215, respectively;
(p) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:29, 71, 111, 153, 181, and 214, respectively;
(q) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:33, 75, 117, 156, 161, and 220, respectively;
(r) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:9, 42, 85, 127, 167, and 192, respectively;
(s) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:7, 40, 83, 125, 165, and 190, respectively;
(t) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:9, 60, 103, 143, 167, and 192, respectively;
(u) an HVR-H1, HVR-H2, HVR-H3, HVR-11, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:21, 61, 104, 144, 169, and 209, respectively;
(v) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:16, 50, 93, 134, 172, and 199, respectively;
(w) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:13, 46, 89, 141, 171, and 206, respectively;
or
(x) an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of SEQ ID NOs:22, 62, 105, 145, 161, and 210, respectively.

23 more elements

Facts

Application

16/959,081Filed 21 Dec 2018 · us provisional application

Priority

29 Dec 2017

Published

US 2020/0339680 A129 Oct 2020

Granted

13 Sep 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07K 16/18
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against material from animals or humans
C07K 16/28
Against material from animals or humans: against receptors, cell surface antigens or cell surface determinants
C07K 2317/33
Characterized by aspects of specificity or valency: crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
C07K 2317/34
Characterized by aspects of specificity or valency: identification of a linear epitope shorter than 20 amino acid residues or of a conformational…