Anti-VEGF protein compositions and methods for producing the same

A recombinant polypeptide having IdeS protease activity comprising the amino acid sequence selected from the group consisting of SEQ ID NO.:

• 2, SEQ ID NO.:
• 3, SEQ ID NO.:
• 4, SEQ ID NO.:
• 5, SEQ ID NO.:
• 6, SEQ ID NO.:
• 7, SEQ ID NO.:
• 8, SEQ ID NO.:
• 9, SEQ ID NO.:
• 10, SEQ ID NO.:
• 11, SEQ ID NO.:
• 12, SEQ ID NO.:
• 13, SEQ ID NO.:
• 14, SEQ ID NO.:
• 15 and SEQ ID NO.:
• 16, wherein said polypeptide has the IdeS protease activity at a basic pH.