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US 11,440,945 B2Granted
Systems and methods to improve vaccine efficacy
AssigneeFred Hutchinson Cancer Center
InventorMatthias Stephan
Life of this patent
Estimating the term…
Abstract
Systems and methods to increase the efficacy of vaccines that require or are rendered more effective with T cell mediated immunity are described. The systems and methods utilize polynucleotides that genetically modify T cells to express a T cell receptor specific for an administered vaccine antigen.
Claims28
A method, comprising
- administering a vaccine antigen to a subject;
- and
- administering an effective amount of a nanoparticle to the subject;
- wherein the nanoparticle comprises
- (i) a polynucleotide encoding a T cell receptor (TCR) that specifically binds the vaccine antigen;
- and
- (ii) a binding fragment of an anti-CD4 or anti-CD8 antibody exposed on the surface of the nanoparticle.
4 more elements
A composition, comprising:
- a vaccine antigen;
- and
- an effective amount of a nanoparticle,
- wherein the nanoparticle comprises
- (i) a polynucleotide encoding a T cell receptor (TCR) that specifically binds the vaccine antigen;
- and
- (ii) a binding fragment of an anti-CD4 or anti-CD8 antibody exposed on the surface of the nanoparticle.
4 more elements
A method, comprising:
- administering an effective amount of a nanoparticle to a subject vaccinated with a vaccine antigen;
- wherein the nanoparticle comprises:
- (i) a polynucleotide encoding a T cell receptor (TCR) that specifically binds the vaccine antigen;
- and
- (ii) a binding fragment of an anti-CD4 or anti-CD8 antibody exposed on the surface of the nanoparticle.
2 more elements
Dependencies are inferred from the claim text.