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US 11,440,942 B2Granted
Complement factor based affinity chromatography
AssigneeHoffmann-La Roche Inc.
InventorsAlexander Knaupp, Laurent Lariviere, Petra Rueger, Tilman Schlothauer, Stefan Seeber
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Abstract
Herein is reported a fusion polypeptide according to formula I (TAG-X1-C1qA-X2-C1qB-X3-C1qC-X4), comprising a fragment of SEQ ID NO: 01 (C1qA), a fragment of SEQ ID NO: 03 (C1qB), a fragment of SEQ ID NO: 05 (C1qC) and optionally a tag (TAG).
Claims12
A fusion polypeptide according to formula I
- TAG-X1-C1qA-X2-C1qB-X3-C1qC-X4 (formula I)
- wherein
- X1 denotes a first peptidic linker, X2 denotes a second peptidic linker, X3 denotes a third peptidic linker, X4 denotes a fourth peptidic linker,
- X1, X2, X3, X4 are independently of each other either present or absent, TAG is an amino acid sequence tag,
- TAG can be present or absent,
- C1qA has the amino acid sequence of SEQ ID NO:
- 07 is a fragment of SEQ ID NO:
- 01, C1qB has the amino acid sequence of SEQ ID NO:
- 08 is a fragment of SEQ ID NO:
- 03, C1qC has the amino acid sequence of SEQ ID NO:
- 09 is a fragment of SEQ ID NO:
- 05, and
- - denotes a peptide bond.
10 more elements
Dependencies are inferred from the claim text.