Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same
AssigneeEnterin, Inc.
InventorMichael Zasloff
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Abstract
This invention relates to methods of stimulating the activity of the human and animal enteric nervous system. The method comprises orally administering an aminoserol, such as squalamine, a naturally occurring aminosterol isolated from Squalus acanthias, or derivatives thereof, to a subject in need.
Claims11
A method of treating neurodegenerative processes associated with dementia of aging comprising orally administering to a subject in need thereof a composition comprising a pharmaceutically acceptable grade of at least one aminosterol, or a salt thereof, in an effective amount sufficient to produce a beneficial neuro-protective effect in the subject, wherein the aminosterol is squalamine or a pharmaceutically acceptable salt thereof, or Aminosterol 1436 or a pharmaceutically acceptable salt thereof;
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- wherein the effective amount is established by defining the initial dose required to induce the Aminosterol-Induced GI Response, which is the initial dose required to stimulate a change in bowel activity, nausea, secretory diarrhea, or any combination thereof.
Dependencies are inferred from the claim text.