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US 11,440,935 B2Granted
3″,5″-dimethoxybenzoyl-3′-amino-3′-deoxy adenosine-5′-triphosphates and pharmaceutical uses thereof
AssigneeMerck Patent GmbH
InventorsAmir Pelleg, Anu Mahadevan, Jie Li, Cynthia Morency
Life of this patent
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Abstract
Provided are compounds compound according to Formula (I), or a pharmaceutically acceptable salt, solvate, coordination complex or prodrug thereof: wherein, R1 and R2 are independently selected from (C1-C6) alkyl. The compounds have P2X3 receptor or P2X2/3 receptor antagonist activity and are useful for the treatment of diseases and disorders characterized by activation of those receptors.
Claims19
A compound according to Formula (I), or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 and R2 are independently selected from (C1-C6) alkyl.
A process for preparing a compound according to Formula (I),
- wherein:
- R1 and R2 are independently selected from (C1-C6) alkyl;
- the process comprising:
- (a) reacting the compound 1
- with a compound of Formula (IIa)
- to form a compound according to Formula (III);
- (b) 5′-phosphorylating the compound according to Formula (III) to provide a compound according to Formula (I).
4 more elements
Dependencies are inferred from the claim text.